The Kyowa Kirin Sponsored Hypophosphatemia Program
Sponsored, no-charge genetic testing
US and Canada
What is the Kyowa Kirin Sponsored Hypophosphatemia Program?
- A no-charge genetic testing and counseling program for patients being evaluated for a diagnosis of X-linked hypophosphatemia (XLH) or tumor induced osteomalacia (TIO,) who meet certain age requirements and other eligbility criteria
- A program intended to improve patient safety and quality of care by shortening the time to an accurate diagnosis, facilitating prompt confirmatory testing, and helping patients with XLH or TIO meet payor coverage requirements
- Healthcare professionals or patients using this program are not obligated to recommend, purchase, order, prescribe, promote, administer, use, or support any Kyowa Kirin product
- No patients, healthcare professionals, or payers, including government payers, are billed for this program
Genetic Testing Panel and Counseling
Certain hypophosphatemic disorders have an underlying genetic cause. It is equally important to exclude genetic causes of hypophosphatemia when evaluating for a possible diagnosis of TIO. An accurate diagnosis may impact the clinical management of the condition, including customizing care to a patient's specific needs.
About XLH
- XLH, the most common form of genetic hypophosphatemia, is caused by pathogenic variants in the PHEX gene.1 XLH is an X-linked condition, meaning that the genetic variant (located on the X chromosome) only needs to exist in one copy of a patient’s genes to cause the condition.
- Women with XLH have a 50% chance of passing the condition to their children, regardless of gender, while men with XLH will pass it on to all their daughters and none of their sons.2
About TIO
- TIO is a paraneoplastic condition of abnormal phosphorus and vitamin D metabolism caused by small, benign endocrine tumors that secrete the phosphaturic hormone, fibroblast growth factor 23 (FGF23), leading to impaired bone metabolism.3
Testing options
This program offers testing with the Kyowa Kirin Sponsored Hypophosphatemia Panel
Note: Re-requisitions are not available through this sponsored testing program
The panel tests for 13 genes
Kyowa Kirin Sponsored Hypophosphatemia 13 Gene Panel
CLCN5, CTNS, CYP2R1, CYP27B1, DMP1, ENPP1, FGF23, OCRL, PHEX, SLC34A1, SLC34A3, SLC9A3R1, VDR
Genetic counseling services
Individuals in the US and Canada tested through this program are eligible for post-test genetic counseling to help them understand their test results. This service is made available by Invitae at no charge as part of the program. Patients can access genetic counseling by scheduling a session through their patient portal or by contacting Invitae Client Services at 1-800-436-3037 and asking to schedule a genetic counseling appointment.
- If you are using an outside lab to collect the sample, it is recommended that you fax the TRF to Invitae at 415-276-4164
- Kyowa Kirin DOES NOT compensate HCPs or labs for specimen collection or handling
- Kyowa Kirin will not receive any individual test result data, personally identifiable information, or physician ordering information. Any data that may be transmitted will be de-identified and aggregated
Questions? Contact Invitae