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PATH4WARD Program

Sponsored, no-charge genetic testing
US

Logo: Path4ward

What is the PATH4WARD program?

PATH4WARD is a no-charge genetic testing program sponsored by X4 Pharmaceuticals in partnership with Invitae, intended to help diagnose patients suspected of having a congenital neutropenic disorder or a primary immunodeficiency (PID), including WHIM syndrome. The program includes genetic counseling for patients and/or clinicians, as well as family variant testing when applicable.

Genetic testing may help you to:

Confirm a suspected diagnosis


Guide patient management


Provide information to support participation in clinical trials


Determine if a particular condition runs in the family


Program eligibility

The no-charge PATH4WARD genetic testing program is available to US patients who have all three (3) of the following criteria:

  • 1. Suspicion of a congenital neutropenic disorder or a primary immunodeficiency.

  • 2. Any prior history or a current absolute neutrophil count (ANC) ≤ 1,000 cells/µL on multiple occasions that is not related to drugs or chemotherapy or secondary to viral infection.

  • 3. One or more of the following:

    • Personal history - or family history - of recurrent and/or severe infection
    • Personal history of lymphopenia
    • Personal history of hypogammaglobulinemia
    • Personal history of refractory or recalcitrant warts
    • Family history of neutropenia

Test option

This program offers testing with the following panel. Learn more about the panel in our test catalog before placing your order on this program page.

How to order

Our easy-to-order panels align with professional guidelines, making your potential next steps clearer.

  • Step 1 duotone icon

    Step 1

    Discuss testing and get consent from the eligible patient. Place your order via our convenient online portal.

  • Step 2 duotone icon

    Step 2

    Collect your patient’s specimen using an Invitae collection kit and return it. Use the label provided to ship most samples at no additional charge from the US and Canada.

  • Genetic testing expert - Invitae icon

    Step 3

    Receive results online and access resources to guide your discussion with patient about their results.

Next steps and additional services

Woman smiling while providing genetic expert support

Genetic counseling services

Individuals in the US tested through the PATH4WARD program are eligible for post-test genetic counseling to help them understand their test results. This service is made available by Invitae at no charge as part of the program. Patients can access genetic counseling by using an online scheduling option or by contacting Invitae Client Services at 1-800-436-3037 and asking to schedule a genetic counseling appointment.

About X4 Pharmaceuticals, Inc.

X4 Pharmaceuticals is a late-stage clinical biopharmaceutical company and a leader in the discovery and development of novel therapies for the treatment of rare diseases of the immune system, with a focus on CXCR4 chemokine receptor biology. We are advancing innovative therapies to help improve the lives of people with immunodeficiencies, including WHIM syndrome and Chronic Neutropenic disorders.

Disclaimer: This is a sponsored testing program. While third parties and commercial organizations may provide financial support for this program, tests and services are performed by Invitae. Healthcare professionals must confirm that patients meet certain criteria to use the program. Third parties and commercial organizations may receive de-identified (pseudonymized) patient data from this program, but at no time would they receive patient identifiable information. Third parties and commercial organizations may receive contact information for healthcare professionals who use this program. Genetic testing and counseling are available in the US and Canada. Healthcare professionals and patients who participate in this program have no obligation to recommend, purchase, order, prescribe, promote, administer, use or support any other products or services from Invitae or from third parties or commercial organizations.

X4NM-US-001-2300009 (v1.0)