Invitae Unlock™ Immunology Program
A new genetic testing program
US
Introducing the Invitae UnlockTM genetic testing program
Invitae UnlockTM program expands timely access to genetic insights for patients who may have a hereditary condition. Together, we can provide information that helps guide the best care path forward for patients and supports personal health treatment options for patients with genetic conditions.
Invitae UnlockTM Immunology
Support your patients' options to access genetic testing through our new genetic testing program.
Program eligibility
This program is available to individuals in the United States with a clinical suspicion for an inborn error of immunity, including primary immunodeficiencies and primary immune regulatory disorders based on one more of the following:
Hematology/Immunology/Lymphoid/Rheumatology
- Athymia
- Autoimmune hemolytic anemia/Autoimmune cytopenia/Immune thrombocytopenia
- Autoinflammatory condition
- Bone marrow hypocellularity
- Bone marrow failure
- Hemophagocytosis
- Lymphadenopathy
- Lymphoma
- Leukemia
- Myelokathexis
- Opportunistic infections
- Recurrent infections
- Recurrent/periodic fevers
- Rheumatoid arthritis, juvenile onset
- Poor response to treatment for infections
- Severe combined immunodeficiency (SCID)
- Usually mild childhood disease which has worsened or has become life-threatening
Laboratory
- Abnormal immunoglobulins
- Abnormal oxidative burst
- Abnormal response to vaccines
- Abnormal T cell proliferation
- Abnormal T cell subsets
- Absent/low TRECs on SCID newborn screening
- Absent perforin staining
- Agammaglobulinemia/hypogammaglobulinemia
- Autoimmune hemolytic anemia
- Elevated levels of immunoglobulin M
- Increased chromosomal breakage
- Increased inflammatory markers
- Increased interleukin-2 soluble receptor alpha (IL2Ra)
- Increased activated T cell number
- Low pneumococcal vacine titers
- Neutropenia
- Oligoclonal T cells
- Pancytopenia
- Reduced B cell subset
- Reduced number of T cells
- Short telomere length
- Thrombocytopenia
- Transplacentally acquired maternal engraftment of T cells
Dermatology
- Telangiectasias
- Recalcitrant warts
- Molluscum, severe
- Severe, recurrent skin infections
- Scleroderma
Gastroenterology
- Chronic hepatomegaly
- Chronic splenomegaly
- Very early onset inflammatory bowel disease, onset <6 years of age
- Protein enteropathy
Pulmonary
- Bronchiectasis
- Interstitial lung disease
- Pulmonary fibrosis
Family History
- Relative with an inborn error of immunity and a positive genetic test result
How to order
1. Submit an order*
Place an order online or via paper, including your patient's insurance information.
* Invitae will determine if genetic testing is covered. If so, we will bill your patient’s insurance carrier once results have been released. If your patient does not have insurance benefits, the patient’s insurance policy does not cover genetic testing, or your patient does not meet their payer’s eligibility criteria, they may be eligible for a sponsored, no-charge testing option. Under this program, de-identified patient information and clinician contact information may be shared with third parties, such as researchers and commercial entities, regardless of the billing method used.
2. Collect a specimen
Order a blood, buccal or saliva collection kit.
3. Receive results
On average, we return results within 10–21 days after receiving the specimen.
Additional resources
Intuitive services and resources, available when you need them.
Interpretation support
Reports come with clear information about potential next steps. For many results, Invitae offers detailed gene-specific guides created by experts.
Genetic counseling
Invitae’s genetic counselors can help review results and identify relevant management guidelines and resources.
Educational webinars
Stay up to date on the most important issues in genetics today by joining any of our Invitae-hosted webinars.