Mission: Genome™ - Danon Disease Program
Sponsored, no-charge genetic testing
US
What is the Mission: GenomeTM - Danon Disease Program?
The Mission: Genome – Danon Disease Program can help provide answers for those with suspected Danon Disease. Through the program, individuals suspected of having Danon Disease have access to genetic testing and counseling to help bring them one step closer to a diagnosis and the appropriate clinical management. No patients, healthcare professionals, or payers, including government payers, are billed for this program.
- Approximately 15,000 patients in the United States are living with Danon Disease1
- Danon Disease symptoms include signs of heart disease, electrocardiogram abnormalities, muscle abnormalities, neurocognitive conditions, ophthalmologic manifestations, and/or gastrointestinal involvement2
- It’s important to identify the signs of Danon Disease and diagnose it early. Danon Disease can rapidly progress to stroke, heart failure requiring a transplant, and even sudden cardiac death related to arrhythmias. Early identification may help guide proper care and monitoring for signs of progression3
Program eligibility
This program is available to patients in the United States, 50 years of age or younger, with a high suspicion of an inherited cardiomyopathy. Must meet at least one of the criteria below:
- A family history of Danon Disease
- Diagnosis of hypertrophic or dilated cardiomyopathy with an onset of symptoms 18 years of age or younger
- Meets at least three (3) of the following:
- Suspicion or diagnosis of cardiomyopathy, heart failure, or arrhythmia
- Family history of cardiomyopathy, arrhythmia, heart failure, or unexplained sudden cardiac death
- Documented evidence of muscle disease/unexplained myopathy (abnormal EMG, elevated CPK/elevated liver enzymes, abnormal muscle biopsy) or proximal muscle weakness
- Developmental delay or intellectual disability
- Retinopathy
How to order
Our easy-to-order panels align with professional guidelines, making your potential next steps clearer.
Step 1
Discuss testing and get consent from the eligible patient. Place your order via our convenient online portal.
Step 2
Collect your patient’s specimen using an Invitae collection kit and return it. Use the label provided to ship most samples at no additional charge from the US.
Step 3
Receive results online and access resources to guide your discussion with patient about their results.
Next steps and additional services
Family variant testing
If your patient is found to have a disease-causing or likely disease-causing variant, we can test their family members for that variant
- All blood relatives of patients tested through this sponsored testing program and found to have a pathogenic or likely pathogenic variant are eligible
- Family variant testing reports on the variant(s) that was identified in the original family member, as well as any other pathogenic variant(s) found in the gene
Re-requisition
If you don't get the answers you need on your first panel, expand to more genes at no additional charge
- Invitae's re-requisition service is offered at no additional charge for 150 days after your patient's first report
- No new specimen is required
Genetic counseling services
Individuals in the US tested through the Mission: Genome - Danon Disease Program are eligible for post-test genetic counseling to help them understand their test results. This service is made available by Labcorp Genetics at no charge as part of the program. Patients can access genetic counseling by using an online scheduling option or by contacting Client Services at 1-800-436-3037 and asking to schedule a genetic counseling appointment.